Chicken Egg Yolk Antibodies (IgYs) block the binding of multiple SARS-CoV-2 spike protein variants to human ACE2 – PubMed
The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro. It might be a feasible tool for the prevention and control of ongoing COVID-19.
Keywords: Chicken Egg Yolk Antibodies; IgY; Neutralizing agent; SARS-CoV-2; Spike protein variants.
Copyright © 2020 Elsevier B.V. All rights reserved.
MeSH terms
- Angiotensin-Converting Enzyme 2 / metabolism*
- Animals
- Antibodies, Neutralizing / metabolism*
- Antibodies, Neutralizing / therapeutic use
- COVID-19 / therapy*
- Chickens / immunology*
- Egg Yolk / metabolism*
- Humans
- Immunoglobulins / metabolism*
- Immunoglobulins / therapeutic use
- Mutation / genetics
- Pandemics
- Protein Binding
- SARS-CoV-2 / genetics
- SARS-CoV-2 / metabolism*
- Spike Glycoprotein, Coronavirus / genetics
- Spike Glycoprotein, Coronavirus / metabolism*
Substances
- Antibodies, Neutralizing
- IgY
- Immunoglobulins
- Spike Glycoprotein, Coronavirus
- spike glycoprotein, SARS-CoV
- ACE2 protein, human
- Angiotensin-Converting Enzyme 2
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