Many peer-reviewed research articles conclusively demonstrate that a low level of 25-hydroxyvitamin D in the bloodstream significantly increases the risk of severe disease, long-term damage, and death from COVID-19. That this information remains relatively unknown three years after the onset of the pandemic can be attributed to a pervasive pattern of corruption and/or glaring incompetence among many doctors, immunologists, public health officials, and mainstream media outlets.
In this article, we highlight research into the immune system’s dependence on the three “vitamin D” compounds: vitamin D3 cholecalciferol, 25-hydroxyvitamin D calcifediol and 1,25-dihydroxyvitamin D calcitriol. Only the first is a vitamin and all three molecules have very different roles. Only calcitriol can function as a hormone, but the immune system does not use hormonal signaling.
“Vitamin D” blood tests measure the level (concentration) of 25-hydroxyvitamin D in the bloodstream, because both the kidneys and the immune system rely on this as a supply for their signaling functions, which involve hydroxylating it to 1,25-dihydroxyvitamin D. 25-hydroxyvitamin D is made primarily in the liver, from vitamin D3 which is either ingested or is produced by the action of short-wavelength, high energy, ultraviolet B radiation on the skin.
In most populations, average 25-hydroxyvitamin D levels are half or less than the 50 ng/mL (125 nmol/L) required for optimal immune system function. Additionally, we explain the 25-hydroxyvitamin D-based intracrine and paracrine signaling systems which many types of immune cells rely on to respond to their changing circumstances. Furthermore, we present a vitamin D supplementation protocol that reliably attains at least 50 ng/mL of 25-hydroxyvitamin D over several months, along with methods for achieving this level in clinical emergencies within approximately four days or even four hours.
There is very little vitamin D3 in food. UV-B radiation is difficult to obtain except on cloudless days with high elevation sunlight – and it always damages DNA and so raises the risk of skin cancer.
Good health can only be obtained with at least 50 ng/mL circulating 25-hydroxyvitamin D. This is the only way of ensuring that SARS-CoV-2 and influenza do not spread in pandemic fashion and do not seriously harm and kill many of those who are infected. Sepsis, which kills around 11 million people a year worldwide, would be rare if everyone had at least 50 ng/mL circulating 25-hydroxyvitamin D.
Fortunately, very small quantities of vitamin D3 are required – and it is safe, inexpensive and well-researched.
We also discuss the excessive, indiscriminate cell destroying, inflammatory immune responses which are the cause of most of the harm and death from COVID-19 and which cause numerous other acute and chronic illnesses, especially sepsis. Inadequate 25-hydroxyvitamin D makes these responses much worse, but their fundamental cause is an evolutionary adaptation to helminths (intestinal worms) which is exposed now that we are no longer infested with these multicellular parasites.
Vulnerable Populations and Vitamin D Deficiency
Elderly individuals, those with dark or black skin living far from the equator, and people who avoid exposure to ultraviolet B light typically have even lower levels of 25-hydroxyvitamin D than those who are younger, with less pigmented skin, who live closer to the equator or who expose more…